Name

CAS No.

%w/w

CURCUMA COMOSA RHIZOME EXTRACT

-

4-16

Propylene glycol

57-55-6

q.s. to 100

Phenoxyethanol

122-99-6

1

Caprylhydroxamic acid

7377-03-9

0.05

Botanical name

Curcuma comosa Roxb.

Part of plant used

Rhizome

Physical state and appearance

Liquid

Color

Light brown to brown

Odor

Slightly characteristic

pH

5.0 +/- 1.0

Specific gravity

1.02 +/- 0.20

Used

References

Treatment of fluatalence and gynecologic diseases such as premenstrual syndrome (PMS), abnormal menstruation and uterine pain.

รองศาสตราจารย์ พร้อมจิต ศรลัมพ์. บทความเผยแพร่ความรู้สู่ประชาชน, ว่านชักมดลูก.
http://www.pharmacy.mahidol.ac.th/th/knowledge/article/92/ว่านชักมดลูก
Accessed: 7 Dec 2017

Curcuma comosa. https://en.wikipedia.org/wiki/Curcuma_comosa
Accessed: 7 Dec 2017

Keeratinijakal, V., Kongkiatpaiboon, S. (2017) Distribution of phytoestrogenic diarylheptannoids and sesquiterpenoids components in Curcuma comosa rhizomes and its related species. Revista Brasileira de Farmacognosia 27: 290-296.

Winuthayanon, W., Piyachaturawat, P., Suksamrarn, A., Ponglikitmongkol, M., Arao, Y., Hewitt, S.C., Korach, K.S. (2009) Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biological actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms. Environmental Health Perspectives 117: 1155-1161.

Anti-inflammatory properties

Curcuma comosa. https://en.wikipedia.org/wiki/Curcuma_comosa
Accessed: 7 Dec 2017

Biological activity

References

Estrogenic

Winuthayanon, W., Piyachaturawat, P., Suksamrarn, A., Ponglikitmongkol, M., Arao, Y., Hewitt, S.C., Korach, K.S. (2009) Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biological actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms. Environmental Health Perspectives 117: 1155-1161.

Winuthayanon, W., Suksen, K., Boonchird, C., Chuncharunee, A., Ponglikitmongkol, M., Suksamrarn, A., Piyachaturawat, P. (2009) Estrogenic activity of diarylheptanoids from Curcuma comosa Roxb. Requires metabolic activation. Journal of Agricultural and Food Chemistry 59: 840-845.

Bhukkhai, K., Suksen, K., Bhummaphan, N., Janjorn, K., Thongon, N., Tantikanlayaporn, D., Piyachaturawat, P., Suksamrarn, A., Chairoungdua, A. (2012) A phytoestrogen diarylheptanoid mediates estrogen receptor/Akt/glycogen synthase kinase 3β protein-dependent activation of the Wnt/β-catenin signaling pathway. The Journal of Biological Chemistry 287: 36168-36178.

Uterotrophic

Piyachaturawat, P., Ercharuporn, S., Suksamrarn, A. (1995) Uterotrophic effect of Curcuma comosa in rats. International Journal of Pharmacognosy 33: 334-338.

Anti-inflammatory

Jantaratnotai, N., Utaisincharoen, P., Piyachaturawat, P., Chongthammakun, S., Sanvarinda, Y. (2006) Inhibitory effect of Curcuma comosa on NO production and cytokine expression in LPS-activated microglia. Life Science 78: 571-577.

Sodsai, A., Piyachaturawat, P., Sophasan, A., Suksamrarn, A., Vongsakul, M. (2007) Suppresion by Curcuma comosa Roxb. of pro-inflammatory cytokine secretion in phorbol-12-myristate-13-acetate stimulated human mononuclear cells. International Immunopharmacology 7: 524-531.

Anti-oxidant

Niumsakul, S., Hirunsaree, A., Wattanapitayakul, S., Junsuwanitch, N., Prapanupun, K. (2007) An antioxidative and cytotoxic substance extracted from Curcuma comosa Roxb. Journal of Thai Traditional and Alternative Medicine 5: 24-29

Growth suppressing on male reproductive organs

Piyachaturawat, P., Timinkul, A., Chauncharunee, A., Suksamrarn, A. (1998) Growth suppressing effect of Curcuma comosa extract on male reproductive organs in immature rats. Pharmaceutical Biology 36: 44-49.

Male fertility

Piyachaturawat, P., Timinkul, A., Chaunchararunee, A., Suksamrarn, A. (1999) Effect of Curcuma comosa extract on male fertility in rats. Pharmaceutical Biology 37: 22-27.

Enhance vascular relaxation

Intapad, S., Suksamrarn, A., Piyachaturawat, P. (2009) Enhancement of vascular relaxation in rat aorta by phytoestrogens from Curcuma comosa Roxb. Vascular Pharmacology 51: 284-290.

Intapad, S., Saengsirisuwan, V., Prasannarong, M., Chuncharunee, A., Suvitayawat, W., Chokchaisiri, R., Suksamrarn, A., Piyachaturawat, P. (2012) Long-term effect of phytoestrogens from Curcuma comosa Roxb. on vascular relaxation in ovariectomized rats. Journal of Agricultural and Food Chemistry 60: 758-764.

Process of extraction

Maceration and/or sonication

Extracting solvent

Ethanol

Concentration

Distillation in vacuo

Fractionation

-

Plant Extract Ratio

Between 1:1.5 to 1:1

Solubility of the preparation

Alcohol, Water

Total plate count

< 1000 CFU/g

Yeast and Mold

< 1000 CFU/g